Expresión de búsqueda:
AGOUTI SIGNALING PROTEIN
Descriptores Encontrados:
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DeCS
Descriptor
Inglés
:
Agouti Signaling Protein
Descriptor
Español
:
Proteína de Señalización Agouti
Descriptor
Portugués
:
Proteína Agouti Sinalizadora
Categoría:
D12.644.276.049
D12.776.467.049
D23.529.049
Definición
Inglés
:
A secreted protein of approximately 131
amino acids
(depending on species) that regulates the synthesis of eumelanin (brown/black) pigments in
MELANOCYTES
. Agouti protein antagonizes the signaling of
MELANOCORTIN RECEPTORS
and has wide distribution including
ADIPOSE TISSUE
;
GONADS
; and HEART. Its overexpression in agouti mice results in uniform yellow coat color,
OBESITY
, and metabolic defects
similar
to type II diabetes in
humans.
Nota Histórica
Inglés
:
2008 (1993)
Calificadores Permitidos
Inglés
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Número del Registro:
52758
Identificador Único:
D054366
Ocurrencia en la BVS
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS